TABLE 2.
HS diet (2% NaCl, 7 days) caused differential regulation between the R and S rats
Absolute Na+ excretion (UNa+V) was calculated as Urine Na+ × 24-h urine volume. Fractional Na+ excretion (FENa+) was calculated as 100 × (Urine Na+ × Plasma creatinine)/(Plasma Na+ × Urine creatinine). Creatinine clearance was calculated as (Urine creatinine × 24-h urine volume)/(Plasma creatinine × 24 × 60 min). **, p < 0.01 compared to control low salt diet (LS, 0.3% NaCl) of the same strain. #, p < 0.01 the R rats with HS compared to the S rats with HS. n = rat number, per treatment, per group.
| Strain | LS | HS | |
|---|---|---|---|
| BP | R | 133 ± 2.2 (n = 12) | 134 ± 2.6# (n = 12) |
| S | 146 ± 3.1 (n = 12) | 169 ± 5.6** (n = 12) | |
| Plasma Na+ | R | 145 ± 2.8 (n = 12) | 146 ± 1.4 (n = 12) |
| S | 146 ± 2.1 (n = 12) | 147 ± 3.6 (n = 12) | |
| Plasma K+ | R | 8.7 ± 1.8 (n = 12) | 8.6 ± 1.3 (n = 12) |
| S | 8.8 ± 1.4 (n = 12) | 8.7 ± 1.5 (n = 12) | |
| UNa+V (mmol/24 h) | R | 2.9 ± 0.6 (n = 8) | 20.1 ± 1.6**,# (n = 8) |
| S | 2.7 ± 0.25 (n = 8) | 6.5 ± 1.0** (n = 8) | |
| FENa+ | R | 0.073 ± 0.008 (n = 8) | 0.287 ± 0.064**,# (n = 8) |
| S | 0.071 ± 0.004 (n = 8) | 0.132 ± 0.021** (n = 8) | |
| Creatinine clearance (ml/min) | R | 1.99 ± 0.14 (n = 8) | 2.66 ± 0.38 (n = 8) |
| S | 2.06 ± 0.32 (n = 8) | 2.67 ± 0.64 (n = 8) |