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. Author manuscript; available in PMC: 2012 May 20.
Published in final edited form as: Mol Cell. 2011 May 20;42(4):500–510. doi: 10.1016/j.molcel.2011.04.018

Figure 3. miR-128 is a Brain-Enriched, Developmentally Regulated, Neuron-Specific miRNA.

Figure 3

(A) Northern blot analysis of adult mouse tissues. U6 small nuclear RNA (snRNA) is the loading control. Brain (Br), heart (Ht), Intestine (Int), liver (Li), lung (Lu), spleen (Spl), and thymus (Thy).

(B) Northern blot analysis of mouse brains from the indicated embryonic (E) and postnatal (P) time points. U6 snRNA is the loading control.

(C) miR-128 LNA in situ hybridization followed by immunofluorescence analysis of the neuronal marker NeuN in a section of adult mouse brain containing the cerebral cortex and hippocampus (low magnification view).

(D, E) miR-128 LNA in situ hybridization followed by immunofluorescence analysis of adult cerebral cortex (D) and hippocampus (E) (both high magnification views). DAPI staining indicates location of cell nuclei (note the distinct glial cell morphologies revealed by GFAP staining).