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Definitions of isolated tumor cells (ITCs) and micrometastases (MMS)
| Definitions used in EnRoute⊕ Study | ||
|---|---|---|
| Isolated Tumor Cells (ITCs) | Micrometastases (MMs) | |
| Size | < 0.2 mm | 0.2 - 2 mm |
| Localization | No defining criterion | No defining criterion |
| Detection method | HES and/or IHC | HES and/or IHC |
| Formal designation (present vs absent) | pN0i+ vs pN0i- | pN0mi+ vs pN0mi- |
| Designation for study purposes if present | pN0micro+ | pN0micro+ |
HES hematoxylin and eosin stain; IHC immunohistochemistry.
