Table 5.

Promoter methylation in NSCLC-multivariable models assessing smoking history, histologic type, lymph node metastasis, and pleural indentation (OR^† and 95% CI)

Genes	Smoking history	SCC vs. ADC	Lymph node metastasis	Pleural indentation
CALCA	1.07 (0.40-2.88)	2.66 (0.85-8.32)	1.43 (0.46-4.41)	2.19 (0.61-7.79)
CDH1	0.98 (0.37-2.58)	6.77 (1.71-26.8)*	0.78 (0.29-2.13)	5.27 (1.27-21.9)*
DAPK1	0.83 (0.19-3.73)	10.7 (2.16-52.6)*	3.07 (0.32-29.4)	6.98 (1.06-45.8)*
IRX2	0.69 (0.26-1.83)	6.38 (1.77-23.0)*	0.85 (0.31-2.33)	3.89 (1.01-15.0)*
TIMP3	0.78 (0.30-2.02)	3.37 (1.03-11.0)*	1.75 (0.65-4.75)	2.66 (0.77-9.16)
PAX6	0.67 (0.21-2.08)	1.82 (0.50-6.57)	0.77 (0.25-2.38)	2.66 (0.58-12.3)

† OR: odds ratio with 95% confidence interval, adjusted for multiple comparisions.

* Significant at P < 0.05.