Table 2.
Comparison of genes significantly repressed following drug treatment with in-house curated lists of genes.
| Entity list | Genes in entity list present on microarray |
Vancomycin-repressed (1079 genes) |
Bacitracin-repressed (666 genes) |
Moenomycin-repressed (184 genes) |
Repressed by all (118 genes) |
||||
|---|---|---|---|---|---|---|---|---|---|
| Genes in entity list matched with repressed genes |
P-Value | Genes in entity list matched with repressed genes |
P-Value | Genes in entity list matched with repressed genes |
P-Value | Genes in entity list matched with repressed genes |
P-Value | ||
| Amino acid metabolism | 184 | 69 | <1E-30 | 49 | 1.21E-11 | 9 | 0.033121 | ||
| ppGpp-repressed genes | 189 | 147 | <1E-30 | 114 | <1E-16 | 35 | <1E-09 | 25 | <1E-10 |
| Ribosomal protein genes | 53 | 44 | 2.09E-29 | 27 | 1.57E-15 | 4 | 0.03798 | 3 | 0.0479 |
| tRNA synthetases | 28 | 21 | 5.03E-13 | 18 | 3.77E-13 | 3 | 0.028817 | 3 | 0.0088 |
| Conservons | 51 | 28 | 8.20E-12 | 24 | 1.02E-11 | 11 | 2.37E-08 | 10 | 3.87E-09 |
| Coelichelin | 12 | 12 | 5.85E-11 | 12 | 1.72E-13 | 2 | 0.032389 | 2 | 0.014 |
| ABC transport | 227 | 44 | 0.01568 | 48 | 3.85E-09 | 22 | 2.04E-08 | 10 | 0.0025 |
| Glutamate biosynthesis | 27 | 8 | 0.02838 | 7 | 0.00694 | 4 | 0.003681 | 3 | 0.0079 |
| LAXTG sortase substrate | 14 | 5 | 0.03678 | 5 | 0.00506 | 4 | 2.68E-04 | 4 | 4.77E-05 |
| Conservon cvn13 | 4 | 4 | 3.93E-04 | 4 | 5.96E-05 | 3 | 5.37E-05 | 3 | 1.41E-05 |
| Conservon cvn5 | 4 | 4 | 1.53E-07 | 4 | 5.96E-05 | 4 | 3.24E-07 | 4 | 5.37E-08 |
| ATP synthesis | 8 | 8 | 8.99E-07 | 7 | 2.72E-07 | ||||
| Vitamin B12 biosynthesis | 11 | 9 | 1.74E-06 | 7 | 8.86E-06 | ||||
| Peptidoglycan biosynthesis (cytoplasmic) | 14 | 10 | 6.31E-06 | 9 | 3.65E-07 | ||||
| Gly Ser Thr biosynthesis | 35 | 16 | 3.93E-04 | 12 | 2.19E-05 | ||||
| Conservon cvn10 | 4 | 4 | 3.93E-04 | 4 | 5.69E-05 | ||||
| Conservon cvn12 | 4 | 4 | 3.93E-04 | 4 | 5.69E-05 | ||||
| Conservon cvn1 | 4 | 4 | 0.00168 | 2 | 0.04030 | ||||
| SigB regulon | 87 | 23 | 0.00698 | 13 | 0.03697 | ||||
| SigR regulon | 26 | 9 | 0.01000 | 8 | 0.00120 | ||||
| Conservon cvn4 | 4 | 3 | 0.00425 | 2 | 0.04030 | ||||
| Methionine biosynthesis | 9 | 5 | 0.00412 | 3 | 0.03702 | ||||
| Phe Tyr Trp biosynthesis | 33 | 11 | 0.00280 | 9 | 0.00155 | ||||
| Conservon cvn2 | 3 | 3 | 2.78E-04 | 2 | 0.02138 | ||||
| Val Leu Ile biosynthesis | 25 | 11 | 7 | 0.00437 | |||||
| Conservon cvn6 | 4 | 2 | 0.04030 | 3 | 5.37E-05 | 2 | 0.0013 | ||
| Amino acid transport | 34 | 5 | 0.001202 | ||||||
| Carotenoid | 7 | 2 | 0.01 | ||||||
| Desferrioxamines | 4 | 3 | 0.00245 | 1151 | |||||
| Histidine biosynthesis | 26 | 6 | 0.02161 | ||||||
| Lysine biosynthesis | 16 | 8 | 6.83E-04 | ||||||