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Expression of the genes encoding the transcriptional activators for switching on production of the CDA, Red and Act biosynthetic clusters is induced following exposure to vancomycin, bacitracin and moenomycin.
| Antibiotic cluster | Activator gene vancomycin | Fold-change increase in expression in the 90 min sample1 | ||
|---|---|---|---|---|
| Vancomycin | Bacitracin | Moenomycin | ||
| CDA | cdaR (SCO3217) | 5.4 | 2.4 | 1.5 |
| Act | actII-ORF4 (SCO5085) | 2.8 | 1.6 | 1.5 |
| Red | redD (SCO5877) | 11.4 | 4.4 | 2.1 |
| Red | redZ (SCO5881) | 5.7 | 3.6 | NA |
