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. 2011 Jun 24;6(6):e21507. doi: 10.1371/journal.pone.0021507

Table 2. Novel putative calcium blades in human proteins.

UniProt ID Protein name Length (residues) Subcellular localization Number of predicted binding motifsa Motif sequences
BBS2_HUMAN Bardet-Biedl syndrome 2 protein (BBS2) 721 Cytoplasm/cilium membrane [94] 2 170 DFDGDGKKE 178 b 251 DLNSDGVNE 259
KPTN_HUMAN Kaptin 436 Cytoplasm/actin filaments [46], [47] 2 317 DVDLDGRPE 325 373 DLTGDGLQE 381
TIP_HUMAN T cell immunomodulatory protein (TIP) 612 Extracellular and/or transmembrane [43] 2 266 DFDGDGHMD 274 338 DYNMDGYPD 346
a

Estimated conservatively: substitutions at the key positions of the DxDxDG motif are only allowed if precedents exist in Figure 3.

b

An Asp174→Glu mutation has been identified in a patient with Bardet-Biedl syndrome [52].