. Author manuscript; available in PMC: 2012 Jul 1.

Published in final edited form as: Contrast Media Mol Imaging. 2010 Nov 21;6(4):189–199. doi: 10.1002/cmmi.417

Table 1.

Average particle diameters and polydispersity extracted from TEM and powder XRD, and lattice parameters of iron oxide crystals before and after functionalization.

Sample	Protocol	Core size (nm) (TEM)	Polydispersity (nm) (TEM)	Crystal size (nm) (XRD)	Lattice Parameters (XRD)
Oleic-acid-MION	-	7.1	1.4	8.6	8.40(2)
Oleic acid-soap-MION	-	7.6	1.9	-	8.36(3)
Stripped MION	a	7.0	2.0	8.6	8.38(2)
DHB-PEG-MION	a	6.9	1.2	-	-
	b	7.0	1.2	7.2	-
Dopamide-PEG-MION	a	7.4	2.1	-	-
	b	6.7	1.2	8.0	8.40(2)
PO₃-PEG-MION	a	6.6	2.0	-	-
	b	5.5	1.0	4.4	8.41(3)
CO₂-PEG-MION	a	7.3	1.4	-	-
Dopamine MION	a	7.56	1.2	-	-
	b	6.6	1.4	-	-
Sinerem®	c	4.9	1.5	6.0	8.37(2)

^a)

stripping of surface-bound oleic acid with ethanol followed by coordination of ligand,

^b)

direct ligand exchange in a biphasic system,

^c)

data from reference 5.