Table 2.
Relaxivities and magnetic characterization of surface-functionalized MION.
| Sample | Protocol |
r2 (mM−1s−1) |
MS (Am2/kg) |
Hce (T) |
MR/MS e |
TB (K) |
|---|---|---|---|---|---|---|
| Oleic acid-MION | - | c | 49 | 0.013 | 0.33 | 34 |
| Oleic acid-soap-MION | - | 134(3) | 71 | 0.023 | 0.38 | 44 |
| Stripped MION | a | c | 29 | 0.014 | 0.26 | 71 |
| Dopamide-PEG-MION | a | 103(2) | - | - | - | - |
| b | 110(3) | 46 | 0.020 | 0.34 | 52 | |
| DHB-PEG-MION | a | 69.4(3) | - | - | - | - |
| b | 83.8(3) | - | - | - | 47 | |
| PO3-PEG-MION | a | 8.2(2) | - | - | - | - |
| b | 79(3) | 56 | 0.0021 | 0.078 | 18 | |
| CO2-PEG-MION | a | 35(3) | - | - | - | 45 |
| Dopamine-MION | a | 30(6) | - | - | - | 77 |
| b | 16(2) | - | - | - | 82 | |
| Sinerem® | d | 53.1 | 94.8 | - | - | 60 |
a)
Stripping of surface-bound oleic acid with ethanol followed by coordination of ligand,
b)
direct ligand exchange in a biphasic system,
c)
not water soluble,
d)
data from Reference 5,
e)
measured at 10 K. R2 = transverse relaxivity at 300 MHz, MS = saturation magnetization, Hc = coercive field, MR = remanence, TB = blocking temperature. Numbers in parentheses indicate standard deviation from three different samples and synthetic batches.