Table 3.
Results of prospective study of oral postmenopausal estrogen use in women that followed up ~10 years later
| Trait | PME use group (N) | Baseline | Follow-up | Unadjusted P value | Age-adj P value | Multivariate-adj P value |
|---|---|---|---|---|---|---|
| Follow up (years) | Overall (443) | 10.06±0.9 | 0.40 | |||
| Never (87) | 10.10±0.9 | |||||
| Past (247) | 10.10±1.0 | |||||
| Current (109) | 9.56±0.8 | |||||
| | ||||||
| Age (years) | Overall | 65.4±9.0 | 76.0±9.1 | <0.0001 | <0.0001 | <0.0001 |
| Never† | 68.8±8.5 | 79.3±8.4 | ||||
| Past† | 65.0±8.8 | 75.7±8.9 | ||||
| Current† | 63.7±9.4 | 74.2±9.5 | ||||
| | ||||||
| Weight (lbs) | Overall | 144.6±24.6 | 143.2±27.6 | 0.03 | 0.03 | <0.05 |
| Never† | 141.7±22.9 | 137.2±24.5 | ||||
| Past | 144.4±23.3 | 143.5±26.7 | ||||
| Current | 147.3±29.0 | 147.4±31.0 | ||||
| | ||||||
| BMI (kg/m2) | Overall | 25.1±4.1 | 25.5±4.7 | 0.05 | 0.05 | 0.06 |
| Never | 24.7±4.1 | 24.6±4.3 | ||||
| Past† | 25.1±4.0 | 25.6±4.7 | ||||
| Current† | 25.3±4.3 | 25.9±4.7 | ||||
| | ||||||
| SBP (mmHg) | Overall | 131.0±21.5 | 131.6±20.2 | <0.05 | <0.05 | 0.05 |
| Never† | 132.3±19.9 | 137.3±20.3 | ||||
| Past | 130.1±21.5 | 130.2±19.9 | ||||
| Current | 132.0±22.6 | 130.2±19.9 | ||||
| | ||||||
| DBP (mmHg) | Overall | 75.4±8.5 | 72.2±9.7 | 0.07 | 0.07 | 0.08 |
| Never | 75.1±8.2 | 73.9±9.8 | ||||
| Past† | 75.2±8.2 | 71.8±10.3 | ||||
| Current† | 76.3±9.3 | 71.9±8.6 | ||||
| | ||||||
| MAP(mmHg) | Overall | 94.0±11.3 | 92.0±11.3 | 0.03 | 0.03 | 0.04 |
| Never | 94.2±10.4 | 95.1±11.5 | ||||
| Past† | 93.5±11.1 | 91.3±11.5 | ||||
| Current† | 94.8±12.3 | 91.3±10.1 | ||||
| | ||||||
| Serum creatinine (mg/dL) | Overall | 0.90±0.16 | 0.97±0.26 | 0.6 | 0.6 | 0.4 |
| Never† | 0.92±0.18 | 1.01±0.32 | ||||
| Past† | 0.90±0.15 | 0.96±0.25 | ||||
| Current† | 0.89±0.14 | 0.97±0.22 | ||||
| | ||||||
| eGFR by MDRD equation (ml/min/1.73 m2) | Overall | 69.0±14.1 | 63.3±16.0 | 0.5 | 0.5 | 0.4 |
| Never† | 67.0±13.8 | 60.3±15.1 | ||||
| Past† | 69.2±14.1 | 64.2±16.5 | ||||
| Current† | 70.0±14.1 | 63.5±15.2 | ||||
| | ||||||
| Natural-log UACR (mg/g) | Overall | 2.56±0.72 | 2.56±0.77 | <0.01 | <0.01 | <0.01 |
| Never† | 2.46±0.67 | 2.77±0.87 | ||||
| Past | 2.60±0.70 | 2.52±0.69 | ||||
| Current† | 2.56±0.78 | 2.49±0.84 | ||||
| | ||||||
| UACR (mg/g) | Overall | 12.4 (7.6-19.1) | 11.9 (7.3-20.3) | |||
| Median (25th-75th quartiles) | Never† | 10.8 (7.2-17.6) | 13.9 (8.3-26.3) | |||
| Past | 13.1 (7.6-20.9) | 11.2 (7.6-19.1) | ||||
| Current† | 12.2 (7.9-18.1) | 11.8 (6.1-20.3) | ||||
Means±standard deviations are reported. eGFR- estimated glomerular filtration rate by Modification of Diet in Renal Disease Equation. UACR- urine albumin: creatinine ratio (natural log due to non-normal distribution). Overall P values are determined by linear mixed models. Multivariate adjustment includes age, weight (obese, overweight, normal BMI), diabetes (Y/N), ever smoker (Y/N), hypercholesterolemia (Total cholesterol ≥200, or on cholesterol lowering medication, Y/N), HTN (as noted above, Y/N, not entered for HTN model).
age- adjusted P value <0.05 at follow-up visit as compared to baseline visit within each group (Never, Past, or Current users). Bold P value signifies P<0.05.