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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Anesth Analg. 2011 May 19;113(1):175–183. doi: 10.1213/ANE.0b013e31821a0258

Figure 1.

Figure 1

Interleukin (IL)-1 β receptor antagonist (IL-1ra, anakinra, 120 mg/kg, i.p.) prevents the mechanical sensitization induced by intraplantar injection of various doses of substance P (SP) or calcitonin-gene related peptide (CGRP). A) SP (300 ng and 1000 ng) caused significant mechanical allodynia lasting between 1 and 6 hours; whereas the anakinra preinjected mice displayed reduced hindpaw mechanical allodynia caused by SP. B) CGRP (3 μg and 10 μg) caused significant mechanical allodynia between 1 and 2 hours; whereas the anakinra preinjected mice displayed reduced hindpaw mechanical allodynia induced by CGRP. Values are means ± SE. N=6 mice for all experimental groups. * p<0.05, ** p<0.01, *** p<0.001 for differences relative to baseline; # p<0.05 for differences between the non-anakinra and anakinra pretreated mice that were injected with the same dose of SP or CGRP.