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Effect of flow rate and duration of exposure to the flow on gene expression. Hepatocytes were cultured as indicated in Fig. 2. Left panels (FT316): effect of rate of medium flow at day 7 on mRNA expression normalized with respect to ribosomal protein, large, P0 (RPLP0) mRNA (arbitrary units). Right panels (FT317): effect of time of exposure to flow (250 μL/min). Black squares: dynamic; white squares: static conditions. *p<0.05 with respect to static conditions; p<0.01 for CYP1As.
