Table 1.
Identification of 31 down-regulated miRNAs from a list of 71 up-regulated mRNAs
| Down-regulated miRNA | miRNA family | No. of mRNA targets | Target genes predicted by the PLS method |
|---|---|---|---|
| *hsa-let-7 g | Let-7 g | 17 | BUD31, COTL1, CPNE1, EIF3B, FTL, GTF3C1, IFITM1, NAP1L4, NUDT1, PHB, PSMC2, PSMC4, PUF60, Ras-Like protein, RPL10, SRD5A3, WDR36 |
| hsa-miR-1 | miR-1 | 1 | RPL10 |
| hsa-miR-100 | miR-100 | 1 | GSTP1 |
| *hsa-miR-101 | miR-101 | 7 | ATP6V0B, GTF2IRD1, GUK1, NEBL, PSMB4, UBE2I, VKORC1 |
| hsa-miR-10b | miR-10b | 2 | MIF, PSMC2 |
| hsa-miR-126 | miR-126 | 16 | ANXA2, CSTB, DDIT4, GPATCH3, GTF2IRD1, GUK1, MDK, NDK, NEBL, OAZ1, PSMB4, S100A11, SLC7A11, TBCD, UBA6, VKORC1 |
| hsa-miR-130a | miR-130 | 2 | GSTP1, RPL34 |
| *hsa-miR-133a | miR-133 | 17 | ANXA2, ATP6V0B, CSTB, GPATCH3, GPX1, GTF2IRD1, NAP1L4, NEBL, OAZ1, POLR2H, PSMB4, RPL10, SLC7A11, TBCD, UBA6, UBE2I, VKORC1 |
| hsa-miR-142-5p | miR-142 | 6 | ARPC1B, DDIT4, GSTP1, MDK, TUFM, USP22 |
| *hsa-miR-150 | miR-150 | 20 | ABHD12, C7orf28A, CLIC1, CPNE1, EIF3B, GSTP1, GTF3C1, IFITM1, LAPTM5, NAP1L4, ODC1, PRDX2, PSMB2, PSMC4, PSMD8, PUF60, RPL10, SRD5A3, TBCD, Wilm's tumor-related protein |
| *hsa-miR-15a | miR-15 | 8 | C7orf28A, CAPG, CPNE1, GTF3C1, NUDT1, PSMD8, WDR36, Wilm's tumor-related protein |
| *hsa-miR-16 | miR-16 | 8 | FTL, GTF3C1, LAPTM5, PHB, PSMD8, SRD5A3, WDR36, Wilm's tumor-related protein |
| hsa-miR-195 | miR-195 | 2 | PSMD8, RPL10 |
| hsa-miR-26a | miR-26 | 3 | CAPG, FTL, GTF3C1 |
| hsa-miR-26b | miR-26 | 15 | ATP6V0B, BUD31, CANX, CAPG, EIF3B, FTL, MIF, NAP1L4, NUDT1, ODC1, POLR2H, PSMC2, PSMC4, UBE2I, WDR36 |
| hsa-miR-28 | miR-28 | 21 | ABHD12, ARPC1B, CLIC1, CPNE1, EIF3B, FTL, GTF3C1, IFITM1, LAPTM5, NAP1L4, ODC1, PRDX2, PSMB2, PSMC4, PSMD8, PUF60, RPL10, RPS9, SRD5A3, TUFM, Wilm's tumor-related protein |
| *hsa-miR-29b | miR-29 | 15 | ANXA2, CDC42SE1, CSTB, DDIT4, GNPTG, GPATCH3, GPX1, ITPA, MDK, PSMB4, S100A11, SLC7A11, USP22, VKORC1, ZNF37A |
| *hsa-miR-29c | miR-29 | 7 | ABHD12, C7orf28A, PSMD8, RPL10, TBCD, USP22, ZNF37A |
| *hsa-miR-30a | miR-30 | 22 | ANXA2, C7orf28A, CAPG, CSTB, DAP, GPATCH3, GPX1, GTF2IRD1, GUK1, ITPA, MMP11, NEBL, NUDT1, OAZ1, POLR2H, PSMB4, SLC7A11, TBCD, UBA6, UBE2I, VKORC1, ZNF37A |
| *hsa-miR-30b | miR-30 | 20 | ANXA2, CDC42SE1, CSTB, DDIT4, GNPTG, GPATCH3, GPX1, GPX4, GSTP1, GTF2IRD1, ITPA, MDK, NDK, OAZ1, PSMB4, S100A11, SLC7A11, USP22, VKORC1, ZNF37A |
| *hsa-miR-30c | miR-30 | 15 | ANXA2, CSTB, GPATCH3, GSTP1, GTF2IRD1, ITPA, MDK, NDK, OAZ1, PSMB4, S100A11, SLC7A11, UBA6, VKORC1, ZNF37A |
| *hsa-miR-30d | miR-30 | 25 | ANXA2, ATP6V0B, BHLHE40, C7orf28A, CAPG, CDC42SE1, CSTB, DAP, DDIT4, GPATCH3, GPX1, GTF2IRD1, MIF, MMP11, NEBL, POLR2H, PSMB4, RPL10, S100A11, SLC7A11, TBCD, UBA6, UBE2I, VKORC1, ZNF37A |
| *hsa-miR-30e | miR-30 | 17 | ATP6V0B, BHLHE40, C7orf28A, CAPG, CSTB, DAP, GPATCH3, GPX1, MMP11, NEBL, NUDT1, OAZ1, POLR2H, RPL10, TBCD, VKORC1, ZNF37A |
| hsa-miR-32 | miR-32 | 5 | C7orf28A, ODC1, PSMD8, RPL10, TBCD |
| *hsa-miR-34b | miR-34 | 12 | BUD31, CANX, EIF3B, FTL, GTF3C1, IFITM1, PHB, PSMC4, PUF60, RPL34, SRD5A3, WDR36 |
| hsa-miR-99a | miR-99 | 19 | ANXA2, CSTB, DDIT4, GPATCH3, GSTP1, GTF2IRD1, MDK, MIF, NDK, NEBL, OAZ1, POLR2H, S100A11, SLC7A11, TBCD, UBA6, UBE2I, VKORC1, ZNF37A |
| mmu-miR-10b | miR-10 | 2 | Ras-Like protein, WDR36 |
| mmu-miR-151 | miR-151 | 13 | ATP6V0B, BHLHE40, C7orf28A, CAPG, GTF2IRD1, MIF, MMP11, NUDT1, OAZ1, POLR2H, RPL10, TBCD, VKORC1 |
| *mmu-miR-342 | miR-342 | 21 | ABHD12, ARPC1B, CLIC1, CPNE1, EIF3B, FTL, GTF3C1, IFITM1, NAP1L4, ODC1, PSMB2, PSMC4, PSMD8, PUF60, RPL10, RPL34, RPS9, SRD5A3, TGFBI, TUFM, Wilm's tumor-related protein |
| rno-miR-140 | miR-140 | 1 | NDK |
| rno-miR-151 | miR-151 | 16 | ANXA2, CDC42SE1, CSTB, DDIT4, GNPTG, GPATCH3, GPX1, GTF2IRD1, ITPA, MDK, MMP11, PSMB4, S100A11, SLC7A11, USP22, ZNF37A |
*miRNAs are selected as cancer-mediators based on the literature.