Table 2.

Cancer genes showing differences in copy number aberration between CRC subtypes.

Gene Symbol 1	Frequency of CN Gain			Frequency of CN Loss			Gene expression profile
	MSS 2	MSI-H 2	P-value	MSS 2	MSI-H 2	P-value	MSS 2	MSI-H 2	Fold-change (p-value)
EGFR	0.62	0	0.0003				926+1088	369+197	2.51 (0.106)
EXT1	0.69	0.06	0.00099				829+285	618+244	1.34 (0.053)
GNAS	0.54	0	0.0011				16843+4876	13486+4555	1.25 (0.082)
HOXA11	0.46	0	0.00361				ND3	ND3	-
HOXA13	0.46	0	0.00361				368+364	496+318	0.74 (0.346)
HOXA9	0.46	0	0.00361				1979+2078	2521+1705	0.79 (0.472)
IKZF1	0.46	0	0.00361				ND3	ND3	-
JAZF1	0.46	0	0.00361				153+128	145+43	1.05 (0.847)
LHFP	0.54	0.06	0.0097				553+486	355+172	1.56 (0.202)
MAFB	0.62	0	0.0003				648+687	711+351	0.91 (0.776)
TOP1	0.54	0	0.0011				156+49	151+40	1.03 (0.768)
MALT1				0.69	0	0.00007	258+79	334+105	0.77 (0.051)

¹ The list of cancer gene from the Cancer Genome Project (http://www.sanger.ac.uk/genetics/CGP/).

² The sample sizes of MSS and MSI-H are 13 and 16, respectively.

³ ND: Genes are not expressed in tumor tissue.