Table 3.
Serum and urine osmolality
| Dexmedetomidine | Placebo | |||
|---|---|---|---|---|
| S-Osmol mosm/kg | U-Osmol mosm/kg | S-Osmol mosm/kg | U-Osmol mosm/kg | |
| 5 min after cannulation | 291 ± 4 | 583 ± 178 | 292 ± 4 | 625 ± 152 |
| 1 min after cross clamp removal | 295 ± 4 | 326 ± 93 | 293 ± 5 | 353 ± 80 |
| 24 h after urinary catheter insertion | 296 ± 9 | 618 ± 117 | 290 ± 7 | 649 ± 85 |
| 48 h after urinary catheter insertion | 294 ± 7 | 579 ± 128 | 295 ± 19 | 506 ± 84 |
There were no significant differences between the groups, effect of time or treatment-time interaction in serum osmolality (S-Osmol). Urine osmolality (U-Osmol) initially decreased in both groups (p < 0.001 for time effect) without treatment effect. However, there was a significant treatment-time interaction in the ANOVA (p = 0.024) and in paired comparisons dexmedetomidine patients had significantly higher values 48 h after urinary catheter insertion (p = 0.02)