Table 1.
Selected differentially modulated genes in MCF-7 cells after γ-T3 (40μm) treatment for 24h
| Gene symbol | Description | Fold Change |
|---|---|---|
| ER Stress | ||
| ATF3 | activating transcription factor 3 | 16.76104 |
| DDIT3/CHOP/GADD153 | DNA-damage-inducible transcript 3 | 8.294404 |
| DNAJB9/ERDJ4 | DnaJ (Hsp40) homolog, subfamily B, member 9 homocysteine-inducible, endoplasmic reticulum | 7.424944 |
| HERPUD1 | stress-inducible, ubiquitin-like domain member 1 pleckstrin homology-like domain, family A, member | 4.355322 |
| PHLDA1 | 1 protein phosphatase 1, regulatory (inhibitor) subunit | 4.127389 |
| PPP1R15A/GADD34 | 15A | 2.75497 |
| DUSP6 | dual specificity phosphatase 6 | 2.609884 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 2.544269 |
| EIF2AK3/PERK | eukaryotic translation initiation factor 2-alpha kinase 3 | 2.522865 |
| Others | ||
| INHBE | inhibin, beta E | 14.74111 |
| ANG | angiogenin, ribonuclease, RNase A family, 5 | 5.37427 |
| CLGN | calmegin | 4.113258 |
| ANG | angiogenin, ribonuclease, RNase A family, 5 | 3.72196 |
| EGR1 | early growth response 1 | 3.705403 |
| CAMTA2 | calmodulin binding transcription activator 2 | 3.528805 |
| EGR1 | early growth response 1 | 3.466066 |
| GDF15 | growth differentiation factor 15 | 3.449369 |
| STCH | stress 70 protein chaperone, microsome-associated, 60kDa | 2.836486 |
| HRK | harakiri, BCL2 interacting protein (contains only BH3 domain) | 2.650593 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 2.642888 |
| JUN | jun oncogene | 2.37199 |
| TGIF1 | TGFB-induced factor homeobox 1 | 2.216848 |
| GPR87 | G protein-coupled receptor 87 | 2.094095 |
| ARF4 | ADP-ribosylation factor 4 | 2.090843 |
| ANXA1 | annexin A1 | 2.019521 |
| MYBL1 | v-myb myeloblastosis viral oncogene homolog (avian)-like 1 | −2.00495 |
| MEGF9 | multiple EGF-like-domains 9 | −2.01284 |
| SOX11 | SRY (sex determining region Y)-box 11 | −2.02478 |
| RET | ret proto-oncogene | −2.13753 |