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. Author manuscript; available in PMC: 2012 Sep 15.
Published in final edited form as: Prostate. 2011 Feb 14;71(13):1390–1400. doi: 10.1002/pros.21355

Figure 3. Induction of telomerase interference (reprogramming of telomerase) in tumor-derived CPC.

Figure 3

(A) MT-hTer expression by qPCR and (B) MT-telomerase activity levels by MT-specific qPCR-TRAP 48 hours after infection with lentivirus expressing MT-hTer/siRNA. (C) Percent apoptosis by TUNEL assay at day 4 after treatment with MT-hTer/siRNA or vector control. (D) Proliferation after treatment with MT-hTer/siRNA or vector control. Data in A-D reflects biological triplicate experiments conducted using CPC cells isolated from 1 patient tumor. All experiments were also repeated in triplicate using 2 additional patient tumors with similar results (data not shown).