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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: J Cell Physiol. 2012 Jan;227(1):27–34. doi: 10.1002/jcp.22721

Figure 3. Protein-protein interaction landscape of essential transcription factors in ESC.

Figure 3

Protein interactomes of ten different transcription factors are integrated to generate a virtual protein-protein interaction landscape in ESC. Interacting partners of Oct4, Nanog, Sall4, Esrrb, Zfp281, Tcfcp2l1, Rex1, Dax1, and Nac1 identified in undifferentiated ESC (blue filled circles) (Wang, et al., 2006, Liang, et al., 2008, Pardo, et al., 2010, van den Berg, et al., 2010, Mallanna, et al., 2010) were integrated with the partner proteins of Sox2 identified during the early stages of ESC differentiation (red filled circle) (Mallanna, et al., 2010).