Table 2.
Relation of life space with AD; core model and sensitivity analyses
| Model | (# incident AD cases / total # subjects) | Hazard Ratio 1 | (95% CI) | χ 21df | P value |
|---|---|---|---|---|---|
| Model 1: Core model | 180 / 1,294 | 1.21 | (1.08—1.36) | 10.78 | 0.001 |
| Model 2: Excluding MCI at baseline | 65/ 930 | 1.29 | (1.08—1.54) | 8.09 | 0.004 |
| Model 3: Excluding MCI at baseline and incident AD in 1st year of follow-up | 61 / 926 | 1.29 | (1.08—1.56) | 7.53 | 0.006 |
| Model 4: Excluding MCI at baseline and incident AD in 1st or 2nd year of follow-up | 48/ 913 | 1.25 | (1.00—1.55) | 3.94 | 0.047 |
| Model 5: Excluding lowest 5% cognitive function at baseline | 139 / 1,227 | 1.28 | (1.12—1.45) | 13.80 | <0.001 |
| Model 6: Excluding lowest 10% cognitive function at baseline | 119 / 1,162 | 1.25 | (1.09—1.44) | 9.75 | 0.002 |
| Model 7: Excluding lowest 15% cognitive function at baseline | 97 / 1,098 | 1.28 | (1.09—1.49) | 9.69 | 0.002 |
1
Based on separate Cox proportional hazards models; all models controlled for age, sex, education, and race. Estimates are for a 1 unit change in life space score (higher score = more constricted life space).