Table 1.

Blood pressure and fasting lipids (52-week evaluable population)

	Exenatide once-weekly → exenatide once-weekly n = 103	Sitagliptin → exenatide once-weekly n= 116	Pioglitazone → exenatide once-weekly n = 100
Blood pressure (mmHg)
SBP (baseline)	127 ± 1	126 ± 1	126 ± 1
Δ weeks 26–52	−0.9 (−3.2 to 1.5)	−2.7 (−4.9 to −0.5)*	−0.6 (−3.0 to 1.7)
Δ weeks 0–52	−2.9 (−5.4 to −0.4) *	−2.9 (−5.3 to −0.6) *	−2.2 (−4.7 to 0.3)
DBP (baseline)	80 ± 1	78 ± 1	79 ± 1
Δ weeks 26–52	−1.2 (−2.7 to 0.3)	−0.4 (−1.9 to 1.0)	+1.1 (−0.5 to 2.6)
Δ weeks 0–52	−2.1 (−3.7 to −0.6) *	−1.3 (−2.8 to 0.2)	−0.4 (−2.0 to 1.1)
Blood lipids (mmol/l)
Total cholesterol (baseline)	4.61 ± 0.11	4.59 ± 0.10	4.79 ± 0.11
Δ weeks 26–52	−0.07 (−0.21 to 0.07)	−0.26 (−0.40 to −0.12)*	−0.34 (−0.48 to −0.19)*
Δ weeks 0–52	−0.05 (−0.20 to 0.10)	−0.20 (−0.34 to −0.06)*	−0.22 (−0.37 to −0.07) *
LDL (baseline)	2.77 ± 0.09	2.74 ± 0.08	2.91 ± 0.10
Δ weeks 26–52	0.00 (−0.12 to 0.13)	−0.09 (−0.20 to 0.03)	−0.14 (−0.27 to −0.02)*
Δ weeks 0–52	−0.03 (−0.17 to 0.10)	−0.09 (−0.21 to 0.04)	−0.12 (−0.25 to 0.02)
HDL (baseline)	1.06 ± 0.02	1.10 ± 0.02	1.08 ± 0.03
Δ weeks 26–52	0.00 (−0.03 to 0.03)	−0.01 (−0.04 to 0.02)	−0.14 (−0.18 to −0.11)*
Δ weeks 0–52	0.07 (0.04 to 0.11) *	0.06 (0.02 to 0.09) *	0.01 (−0.03 to 0.05)
Triglycerides (baseline)†	1.80 ± 0.09	1.63 ± 0.07	1.93 ± 0.09
Δ weeks 26–52	10% (2 to 19) *	2% (−5 to 9)	11% (3 to 20)*
Δ weeks 0–52	0% (−7 to 8)	−6% (−12 to 1)	−7% (−14 to 1)

Baseline data are mean ± se for total cholesterol, LDL and HDL.

Least square mean (95% CI) for change from baseline or week 26 for total cholesterol, LDL and HDL.

^†Geometric mean ± se for triglycerides baseline, and geometric least square mean % change (95% CI) for change from baseline to week 26 for triglycerides.

Δ Change from previous value

^*P < 0.05.

DBP, diastolic blood pressure; SBP, systolic blood pressure.