Table 1.
Vitamin C, steady-state haemoglobin and pulse oximetry data in 23 children with SCA and 18 control siblings
| Variable | Children with SCA | Control siblings | p |
|---|---|---|---|
| Median steady-state plasma vitamin C μmol/L | 12.5 (IQ range 3.1–24.1) | ||
| Mean steady-state haemoglobin* (g/dL) | 7.7 (SD 1.16) (range 5.8–10.9) | ||
| Mean daytime SpO2 (%) | 96.0 (SD 3.68) (range 85–100) | 98.6 (SD 1.95) (range 93–100) | 0.005 |
| Median recorded study duration (h) | 9.47 (IQ range 7.78–10.82) | 9.37 (IQ range 5.98–11.06) | 0.8 |
| Mean overnight SpO2 (%) | 96.3 (SD 4.06) (range 77.9–100) | 97.9 (SD 2.0) (range 91.4–99.9) | 0.1 |
| Mean minimum overnight SpO2 (%) | 85.3 (SD 9.3) (range 65–95) | 85.9 (SD 9.1) (range 63–95) | 0.8 |
| Median delta 12 s Index | 0.38 (IQ range 0.28–0.51) | 0.35 (IQ range 0.23–0.48) | 0.25 |
| Median number of overnight SpO2 dips > 3%/h | 5.19 (IQ range 1.09–7.64) | 2.44 (IQ range 1.11–6.16) | 0.4 |
*
Mean of multiple measurements made at between 3 and 15 routine steady-state (no fever, reported pain, malaria parasites or antigens, or admission within 90-day period) routine clinic visits preceding sleep study.
SpO2 = haemoglobin oxygen saturation; IQ range = interquartile range.