Table 3.
Dose–response data on the tumor-forming capacity of vial 1 MDCK cells in newborn athymic nude mice
| Tumor incidence at indicated cell dose (log10; no. mice in which tumors formed/total no. of mice inoculated) |
||||||
| Experiment no. | 7 | 6 | 5 | 4 | 3 | TPD50 (log10) |
| 1 | NT | 1/1 | 5/5 | 5/5 | 1/4 | 3.3 |
| 2 | NT | 7/7 | Losta | 1/2 | 0/5 | 4.0 |
| 3 | NT | 14/15 | 9/11 | NT | NT | ND |
| Overall incidence | 47/49b | 34/35b | 20/22b | 6/7 | 1/9 | 3.7 |
ND, not determined; NT, not tested
a
Lost due to maternal neglect
bTotal includes data from independent single-dose assays