| Commercially available systems |
| Blume 2008 (8) |
At least 18 years old, diabetes, foot ulcer at least 2 cm2, Wagner grade 2 or 3 |
Active Charcot foot; ulcers not caused by electrical, chemical or radiation burns; collagen vascular diseases; neoplastic ulceration; untreated osteomyelitis; cellulitis; uncontrolled hyperglycemia with HbA1c above 12%; inadequate blood circulation in the legs; hyperbaric oxygen therapy; corticosteroid treatment, immunosuppressant treatment, or chemotherapy; growth factors; skin replacement less than 30 days after the beginning of the trial; enzymatic debridement; pregnant women; breastfeeding mothers |
| Chio 2010 (9) |
Adults, status following removal of a free radial forearm flap |
Not available |
| Keskin 2008 (10) |
Age ≥ 18 years, traumatic leg wounds |
Hemodynamic instability; lack of orientation or inability to cooperate |
| Stannard 2009 (11) |
Age ≥ 18 years, severe open fractures requiring repeat debridement |
Open fractures successfully closed after first operation; infected open fractures; incisions not treatable with NPWT; prisoners; pregnant women |
| Systems not commercially available |
| Bee 2008 (12) |
Age ≥ 18 years, exploratory laparotomy following trauma or emergency surgery, indication for abdominal closure |
Prisoners; pregnant women; life expectancy 7 days or less |
| Mody 2008 (13) |
Acute or chronic wounds in the extremities or sacral region or abdominal wounds that could not be closed by initial surgery |
Wounds in a part of the body where it would be hard to apply negative pressure; ischemic wounds; wounds with exposed intestine or blood vessels; wounds with necrotic tissue that could not be debrided; wounds with fistulas, osteomyelitis, neoplasia; contraindications according to manufacturer; anticoagulant treatment |
| Perez 2010 (14) |
Individual acute or chronic wounds |
Bone injuries; vascular ulcers |
| Saaiq 2010 (15) |
Age ≥ 13 years, acute traumatic wounds up to 6 weeks old, wound surface area at least 9 cm2
|
Diabetes mellitus, neoplasia, or increased tendency to bleed; need for flap surgery |
| Sepúlveda 2009 (16) |
Age ≥ 18 years, type 2 diabetes mellitus, wounds following transmetatarsal amputation of 2 or more adjacent toes or the big toe; caused by infection or reduced blood circulation; adequate circulation in the affected leg; metatarsal pulse volume at least 5 mm, systolic blood pressure at least 15 mmHg, ankle–brachial index at least 0.5, foot pulse palpable or status following successful revascularization |
Active Charcot foot; uncontrolled hyperglycemia with HbA1c above 12%; corticosteroid treatment, immunosuppressant treatment, or chemotherapy; severe nutritional disturbances with albumin levels below 2.1 mg/dL; growth factor treatment or hyperbaric oxygen therapy |
