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Low pH increases mIPSC susceptibility to modulation by flurazepam. (A) Examples of mIPSCs recorded at −70 mV at pH = 6.0 (gray) and pH = 7.2 (black) in the absence (upper traces) and presence of 3 μM flurazepam (lower traces). (B) Statistics of flurazepam effect on mIPSC amplitude at pH 7.2 (black bars), and at pH = 6.0 (gray bars). Note that the acidic pH increased the relative enhancement of mIPSC amplitude by flurazepam. Modified from Wojtowicz et al. (2008) with permission.
