Table 2.
Blood Cell Count in BALB/c Mice Infected with 105 PFU of Seasonal H1N1, HH05 (pH1N1), and HH15 (pH1N1) and with 102 PFU of Human H5N1
| Type of blood cell | Controls | Seasonal H1N1 |
HH05 (pH1N1) |
HH15 (pH1N1) |
Human H5N1 |
||||
|---|---|---|---|---|---|---|---|---|---|
| 3 days p.i. | 6 days p.i. | 3 days p.i. | 6 days p.i. | 3 days p.i. | 6 days p.i. | 3 days p.i. | 6 days p.i. | ||
| WBCs (103/mm3) | 7.3 ± 1.8 | 5.3 ± 1.1 | 7.3 ± 1.3 | 5.0 ± 1.4 | 7.4 ± 1.3 | 4.8 ± 0.4 | 7.8 ± 0.7 | 6.7 ± 1.0 | 2.5 ± 0.6⁎ |
| RBCs (103/mm3) | 10.7 ± 0.7 | 9.4 ± 0.4 | 9.9 ± 0.1 | 10.4 ± 1.6 | 11.3 ± 0.8 | 10.8 ± 0.6 | 11.1 ± 0.3 | 11.4 ± 0.4 | 11.5 ± 0.7 |
| Hb (g/dL) | 19.0 ± 1.2 | 17.3 ± 1.0 | 17.4 ± 0.4 | 18.7 ± 2.4 | 19.9 ± 1.2 | 19.2 ± 1.0 | 19.8 ± 0.3 | 20.0 ± 0.7⁎ | 20.0 ± 1.6 |
| HCT (%) | 49.6 ± 1.7 | 46.4 ± 3.0 | 49.8 ± 0.3 | 48.0 ± 7.2 | 52.1 ± 3.9 | 49.7 ± 3.7 | 50.8 ± 1.6 | 52.9 ± 0.3⁎ | 54.8 ± 2.1⁎ |
| PLTs (103/mm3) | 823 ± 227 | 1007 ± 218 | 967 ± 101 | 620 ± 410 | 778 ± 484 | 591 ± 180 | 598 ± 251 | 870 ± 308 | 1005 ± 25 |
| LYMs (103/mm3) | 5.4 ± 1.1 | 3.6 ± 0.7 | 4.8 ± 1.0 | 3.5 ± 1.2 | 4.1 ± 1.2 | 3.2 ± 0.4 | 4.3 ± 0.8 | 4.0 ± 0.3 | 0.7 ± 0.0⁎ |
| GRAs (103/mm3) | 1.9 ± 0.9 | 1.7 ± 0.5 | 2.5 ± 0.4 | 1.5 ± 0.3 | 3.3 ± 0.2 | 1.6 ± 0.0 | 3.5 ± 0.6 | 2.7 ± 0.7 | 1.8 ± 0.6 |
Data are given as the mean ± SD frequency using individual analysis. Blood samples were taken from three animals per time point, and automated blood cell counts were performed. Statistical analysis was performed with the Student's t-test.
GRA, granulocyte; HCT, hematocrit; LYM, lymphocyte; PLT, platelet; RBC, red blood cell; WBC, white blood cell.
⁎
Asterisk indicates significance.