Figure 5.

Variations in BDNF content in the frontal cortex, amygdala, hippocampus, and hypothalamus determined in rats at 1, 2, and 3 weeks after injection of scrambled Aβ_25-35 peptide (10 μg/rat i.c.v., negative control) or Aβ_25-35 (10 μg/rat i.c.v.). Results are expressed as means ± SEM. One-way analysis of variance: frontal cortex, F_6,57 = 9.05 (P < 0.0001); amygdala, F_6,56 = 8.58 (P < 0.0001); hippocampus, F_6,56 = 8.03 (P < 0.0001); and hypothalamus, F_6,54 = 8.65 (P < 0.0001). *P < 0.05, **P < 0.01 versus control noninjected rats [control group (C)]; ^†P < 0.05, ^††P < 0.01 versus respective scrambled peptide treated rats. The number of animals per group is indicated on data bars.