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. 2011 Jul;179(1):92–103. doi: 10.1016/j.ajpath.2011.03.019

Figure 2.

Figure 2

The effects of LXR activation by GW3965 on mononuclear cell infiltrate in rat kidney allografts 7 and 56 days after transplantation. Phenotyping of the mononuclear cell infiltrate of rat kidney allografts by IHC evidenced a significant reduction of ED1+ macrophages (glomeruli and tubulointerstitium) as well as CD8+ and CD4+ T cells in the tubulointerstitial area of kidney allografts 56 days after transplantation by GW3965; the number of FoxP3+ T cells was also lower in kidney allografts at this time point. The magnitude of glomerular and tubulointerstitial mononuclear cell infiltrate was not significantly different between controls and GW3965-treated grafts 7 days after transplantation. Mean ± SEM; **P < 0.01, ***P < 0.001 versus controls.