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In vitro effects of GW3965 and LXRα overexpression on inflammatory activity of BMDMs. BMDMs were pre-incubated with DMSO (WT and mLXRα-tg) or 3 μmol/L GW3965 dissolved in DMSO (WT) for 16 hours. Both GW3965 treatment and LXRα overexpression resulted in secretion of significantly lower amounts of MCP-1 and MIP-1β after 12 hours. Bar diagrams show mean values ± SEMs for three different experiments; *P < 0.05, **P < 0.01 versus WT.
