Table 3.
Twelve-Gene Predictor of Prostate Cancer Recurrence Following Surgery Using 10 mRNAs and Two microRNAs
| Symbol | Description | Coefficient | References |
|---|---|---|---|
| RAD23B | RAD23 homolog B | 0.070 | 20, 21 |
| FBP1 | Fructose-1,6-bisphosphatase 1 | 0.251 | 7, 10, 22 |
| TNFRSF1A | Tumor necrosis factor receptor superfamily, member 1A | −0.588 | 23, 24 |
| CCNG2 | Cyclin G2 | 0.008 | 39–41 |
| hsa-miR-647 | hsa-miR-647 | −0.318 | |
| LETMD1 | LETM1 domain containing 1 | 0.063 | 42–44, 45 |
| NOTCH3 | Notch homolog 3 | 0.367 | 25, 26 |
| ETV1 | ETS variant gene 1 (ETV1) | 0.179 | 9, 15 |
| hsa-miR-519 days | hsa-miR-519 days | 0.551 | 46 |
| BID | BH3 interacting domain death agonist (BID) | 0.128 | 27, 28 |
| SIM2 | Single-minded homolog 2 | 0.124 | 29–32 |
| ANXA1 | Annexin A1 | −0.143 | 33–36 |
Coefficient is derived from the lasso Cox proportion hazards model and was used for computing the predictive score. Positive coefficients indicate a positive association with recurrence, and negative coefficients a negative association with recurrence.