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SHIP–/– mice develop spontaneous intestinal inflammation. A: The ilea of 6-week-old SHIP+/+ and SHIP–/– mice were compared in situ. SHIP–/– mice have thickened intestines with patchy inflammation (arrow). B: On extraction and extension of each ileum, it was determined that inflammation in the SHIP–/– mice was restricted to the distal ileum. Arrows indicate sites of inflammation.
