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. 2011 Jul;179(1):180–188. doi: 10.1016/j.ajpath.2011.03.018

Figure 2.

Figure 2

Intestinal inflammation in SHIP–/– mice develops between the ages of 4 and 8 weeks (wk) and is histologically similar to CD. A: H&E analysis of SHIP+/+ and SHIP–/– ilea at 4 wk (top) revealed no signs of pathological features in either mouse group. At the age of 8 wk (bottom), the ilea of SHIP–/– mice revealed thickening of the muscularis, immune cell aggregates and infiltrates, and goblet cell hypertrophy. Scale bar = 100 μm. B: SHIP–/– mice (aged 8 wk) shared additional histopathological features with CD, including immune cell aggregates that are organized into poorly formed granuloma-like structures in the muscularis (left) and contain multinucleated giant cells (middle); the ilea revealed signs of bleeding into the lumen (arrows, right). Sections are representative of 12 individual mice examined at the age of 6 to 8 wk. Scale bars: 100 μm (left and middle); 500 μm (right).