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. 2011 Jul;179(1):180–188. doi: 10.1016/j.ajpath.2011.03.018

Figure 4.

Figure 4

SHIP–/– mouse ileal cytokine expression shows a mixed Th2-Th17 profile. Cytokine levels were measured in 8-week-old SHIP+/+ and SHIP–/– mice ileal homogenates. Protein (200 μg) was analyzed for IL-4, IL-5, IL-13, IL-17, IL-23, IL-12p70, and interferon (IFN)-γ expression levels. Graphs show tissue expression levels of representative Th2 (A), Th17 (B), and Th1 (C) cytokines, expressed as mean ± SD signal intensity for four mice per group. IL-4, IL-13, and IL-23 were significantly increased in SHIP–/– mice ilea compared with SHIP+/+ littermate controls. No significant (N.S.) differences were observed for IL-5, IL-17, IL-12p70, or IFN-γ. *P < 0.05 comparing SHIP+/+ with SHIP–/– mice ilea using a Student's t-test with Bonferroni correction. a.u. indicates arbitrary unit.