Figure 4.

The 12 selected chemokines that correlate with metagene 1. A: Heat map of 326 colorectal tumors and 12 genes comprising metagene 1 sorted by the metagene score (mean of probe sets that map to a given 12-gene set of genes). The profile below the heat map demarcates the 10 samples with the highest metagene score and the 11 samples with the lowest metagene score. B: The relationship between patient overall survival and the immune response as quantified by the score of chemokine genes on selected CRCs with known status of ectopic lymph node-like structures confirmed by IHC. CRCs with and without lymphoid structures (high and low metagene 1 scores, respectively) segregated into two groups: overall survival time of <2 years versus >2 years. Scores for the chemokine genes are plotted on the y axis.