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. 2011 Jul;179(1):134–140. doi: 10.1016/j.ajpath.2011.03.006

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© 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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Targeted deletion of Jund leads to severe Crgn in mice. Severity of glomerular injury (scored by assessing glomerular hypercellularity and crescents on a semiquantitative scale, where 0 represents normal) (A), percentage of glomerular crescents (B), and representative H&E-stained glomeruli (C) showing crescent formation in the Jund^-/- mice (day 10 after NTS injection). Serum urea (D) and proteinuria (E) levels are significantly increased in Jund^-/- animals compared with WT controls 10 days after the injection of NTS. The kidney function assessed by measuring serum albumin also showed a significant reduction in serum albumin in Jund^-/- animals when compared with WT controls (F). The numbers of CD68⁺ and CD4⁺ cells per glomerular cross section (gcs) were also significantly increased in the Jund^-/- mice when compared with WT controls (G). Ten mice were used for all of the parameters, except for proteinuria (six mice used). ***P < 0.001.