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. 2011 Jul;179(1):23–29. doi: 10.1016/j.ajpath.2011.03.009

Figure 2.

Figure 2

Ly6C+ inflammatory monocytes/DC promote vascular remodeling in the red pulp. Spleens from mice infected with L. donovani were removed at day 28 after infection and analyzed alongside spleens from naïve mice by IHC. A and B: Spleen sections from naïve mice and infected mice treated with isotype control, Gr-1, or 1A8 from day 21 to day 28 after infection were stained with Meca-32 (A) or with CD31 (B). Original magnification, ×200. C–H: Computer-assisted quantitative morphometry was performed to determine the expression of Meca-32 (C and D) and of CD31 (E and F) in the red pulp and also the expression of CD31 in the white pulp (G and H) of mice treated with Gr-1 (C, E, and G) or 1A8 (D, F, and H). Data were generated from multiple sections examined from at least 5 mice per group. *P < 0.05, **P < 0.01, and ***P < 0.001.