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. 2011 Jul;179(1):23–29. doi: 10.1016/j.ajpath.2011.03.009

Figure 3.

Figure 3

Neither Ly6C+ inflammatory monocytes/DC nor Ly6G+ neutrophils are responsible for white pulp remodeling. Spleens from L. donovani infected mice were removed at day 28 after infection and were analyzed, alongside spleens from naïve mice, by IHC. A and B: Spleen sections from naïve mice and infected mice treated with isotype control, Gr-1, or 1A8 from day 21 to day 28 of infection were stained to identify marginal metallophilic macrophages (CD169; green), B cells (B220; red), and T cells (CD3; blue) (A) and FRC (gp38, green) and FDC (FDCM1, red) (B). Original magnification, ×200. C–F: Computer-assisted quantitative morphometry was performed to determine the expression of gp38 (C and D) and FDCM1 (E and F) in mice treated with Gr-1 (C and E) and 1A8 (D and F). Data were generated from multiple sections examined from at least 5 mice per group. *P < 0.05, **P < 0.01.