Table 2.

Associations between breast cancer outcomes and prediagnosis physical activity (N = 4,643)

	0 MET-h/wk	>0–3.0 MET-h/wk	3.1–8.9 MET-h/wk	9+ MET-h/wk	Ptrend
Moderate- to vigorous-intensity physical activity from walking and recreational activitiesa
Total no. of deaths (n = 350)	119	40	70	121
Age-adjusted HR (95% CI)	1.00	0.79 (0.56–1.14)	0.60 (0.45–0.81)	0.55 (0.43–0.71)	0.0001
Multivariable-adjusted HR (95% CI)	1.00	0.81 (0.56–1.16)	0.67 (0.50–0.91)	0.61 (0.47–0.81)	0.0004
No. of breast cancer deaths (n = 194)	61	21	43	69
Age-adjusted HR (95% CI)	1.00	0.81 (0.49–1.32)	0.72 (0.49–1.07)	0.61 (0.44–0.87)	0.0054
Multivariable-adjusted HR (95% CI)	1.00	0.83 (0.51–1.37)	0.82 (0.55–1.22)	0.71 (0.49–1.03)	0.073
Moderate-intensity physical activity from walking and recreational activities, adjusted for vigorous-intensity physical activityb
Total no. of deaths (n = 350)	129	47	91	83
Age-adjusted HR (95% CI)	1.00	0.79 (0.56–1.10)	0.68 (0.52–0.89)	0.52 (0.40–0.69)	0.0001
Multivariable-adjusted HR (95% CI)	1.00	0.81 (0.58–1.13)	0.75 (0.57–0.99)	0.58 (0.44–0.78)	0.0003
No. of breast cancer deaths (n = 194)	68	28	54	44
Age-adjusted HR (95% CI)	1.00	0.87 (0.56–1.36)	0.77 (0.54–1.10)	0.54 (0.37–0.79)	0.0014
Multivariable-adjusted HR (95% CI)	1.00	0.91 (0.58–1.41)	0.87 (0.60–1.25)	0.60 (0.40–0.90)	0.014

NOTE: Physical activity assessed at baseline visit (i.e., prediagnosis). Adjusted for age, ethnicity, WHI study arm, previous hormone therapy use, BMI, diabetes, alcohol, smoke, total calories, percentage calories from fat, and servings of fruit and vegetables.

^a0 MET-h/wk, n = 1,119; >0–3.0 MET-h/wk, n = 473; 3.1–8.9 MET-h/wk, n = 1,065; 9+ MET-h/wk, n = 1,986.

^b0 MET-h/wk, n = 1,275; >0–3.0 MET-h/wk, n = 600; 3.1–8.9 MET-h/wk, n = 1,283; 9+ MET-h/wk, n = 1,485.