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Comparison of signal transduction pathways for itch. (A) Histamine (his) is a ligand for H1R that activates TRPV1 via phoszpholipase intermediaries PLCβ3 and PLA2. (B) Chloroquine (CQ) activates MrgprA3 leading to TRP channel opening, but the intermediate steps in the pathway are unknown. In the case of both pruritogens, TRPs permit Ca2+ influx, which may also have a signaling role.
