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. 2011 Jun 22;100(12):2904–2912. doi: 10.1016/j.bpj.2011.05.031

Figure 5.

Figure 5

Graded release, variable gain, effect of dyad properties on ECC, and rate dependence of myoplasmic Nai and Cai. (A) Peak LCC Ca flux and peak Ca release flux as a function of transmembrane voltage. (B) Normalized peak LCC Ca flux and peak Ca release flux. (C) ECC gain for three conditions: 1), control (100/15 RyR2/LCC ratio, 2 × 10−19 L dyadic volume); 2), 50/7 RyR2/LCC ratio, 2 × 10−19 L dyadic volume; and 3), 100/15 RyR2/LCC ratio, 6 × 10−19 L dyadic volume. Initial conditions were those of a paced myocyte at 1 Hz. After 5 ms the cell was clamped at the voltage indicated on the x axis. (D) Myoplasmic Nai and Cai rate dependence. Steady-state (after 1000 beats of pacing) Nai, peak Cai and diastolic Cai as a function of cycle length (CL).