Figure 8.

Effect of impaired CSQN buffering capacity on whole-cell behavior. (A) Myoplasmic CaT $\left(\mathrm{C}{\mathrm{a}}_{\mathrm{i}}^{\mathrm{cell}}\right).$ (B) JSR Ca concentration $\left(\mathrm{C}{\mathrm{a}}_{\mathrm{JSR}}^{\mathrm{cell}}\right).$ (C) Ca release flux $\left({\mathrm{J}}_{\mathrm{rel}}^{\mathrm{cell}}\right).$ (D) Fraction of active dyads. The myocyte model is paced at 1 Hz. Insets show ${\mathrm{J}}_{\mathrm{rel}}^{\mathrm{cell}}$ and the fraction of active dyads on an expanded timescale.