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Alternative geometries suggested for myosin VI stepping. (A) A model proposed in Mukherjea et al. (22) and Kim et al. (32) and investigated in this study, which assumes dimerized medial tail (MT) domains (green) and extended proximal tail (PT) domains (blue). (B) A model proposed in Spink et al. (31), which assumes dissociated MT domains and short PT domains (see Fig. 1). Distal tail (DT) domain (orange) and cargo binding domain (CBD; purple) remain the same in the alternative models.
