Figure 1.
Crystal structures of E. coli AK in the ligand free state (PDB 4AKE) (left) and when bound to the two substrate mimicking inhibitor Ap5A (PDB 1AKE). The labeled sites are indicated both in 203 and in 142 by an indole side chain.
Crystal structures of E. coli AK in the ligand free state (PDB 4AKE) (left) and when bound to the two substrate mimicking inhibitor Ap5A (PDB 1AKE). The labeled sites are indicated both in 203 and in 142 by an indole side chain.