Table 1.
Characteristics of DBA2/J mice without (control) and with (diabetes) STZ-induced diabetes.
| Parameter | 10 weeks of DM | 15 weeks of DM | 18 weeks of DM* | ||||||
|---|---|---|---|---|---|---|---|---|---|
| DBA/2J Control | DBA/2J Diabetes | P value | DBA/2J Control | DBA/2J Diabetes | P value | DBA/2J Control | DBA/2J Diabetes | P value | |
| N | 10 | 10 | — | 10 | 10 | — | 13 | 6 | — |
| Body weight (g) | 28.4 ± 1.3 | 24.2 ± 0.6 | .003 | 30.6 ± 0.7 | 23.3 ± 0.8 | .0001 | 28.4 ± 1.2 | 22.8 ± 1.0 | .004 |
| Left Kidney wt (g) | 0.27 ± 0.02 | 0.29 ± 0.01 | NS | 0.30 ± 0.01 | 0.30 ± 0.01 | NS | 0.28 ± 0.01 | 0.34 ± 0.04 | .05 |
| Blood glucose (mg/dl) | 104.6 ± 6.9 | 559.1 ± 9.4 | .0001 | 136.4 ± 9.3 | 561.9 ± 16.3 | .0001 | 109.9 ± 4.9 | 582.2 ± 6.7 | .0001 |
| Urine albumin/Cr (μg/mg) | 52.5 ± 17.4 | 88.0 ± 21.9 | .04 | 67.8 ± 15.5 | 178.3 ± 19.7 | .001 | 18.3 ± 3.1 | 73.6 ± 19.8 | .001 |
*Fewer DBA/2J diabetic mice were available to study at 18 weeks due to increased mortality within this group as described elsewhere [8].