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Reduced β-cell cytokine production does not prevent increased cytotoxic effector molecule expression in diabetogenic CTLs. Comparison of IFNγ secretion (A and B) and GzmB expression (C and D) in dividing 8.3 T cells from the PLN and islets isolated from NOD and NODRIP-SOCS1 recipients. Dot plots (A and C) are gated on total CD8+ T cells and represent multiple experiments. Percentage of IFNγ (γ) and MFI for GzmB expression (D) were calculated as described in Figure 1 (n = 4 to 5).
