Table 1.
Conserved proteins with important roles in haematopoiesis
| Drosophila function | Mammalian function | |
|---|---|---|
| Transcription factors and cofactorsa | ||
| Srp (GATA) | Specification of haemocytes; progenitor maintenance (Lebestky et al., 2000; Lebestky et al., 2003; Tokusumi et al., 2010) | Maintenance of HSCs; lineage commitment; regulation of differentiation (Orkin and Zon, 2008; Braun and Woollard, 2009) |
| Lz (RUNX) | Specification of haemocytes (Lebestky et al., 2000; Lebestky et al., 2003) | Maintenance of HSCs; lineage commitment; regulation of differentiation (Wang et al., 2010) |
| Ush (FOG) | Specification of haemocytes; differentiation of lamellocytes (Lebestky et al., 2000; Sorrentino et al., 2007) | Lineage commitment; regulation of differentiation (Tsiftsoglou et al., 2009) |
| Col (EBF) | Maintenance of PSC cells (Crozatier et al., 2004; Krzemien et al., 2007) | B-cell differentiation; maintenance of the niche (Lin and Grosschedl, 1995; Kieslinger et al., 2010) |
| Antp (HOX) | Formation of the PSC (Jung et al., 2005) | HSC proliferation and self-renewal; myelopoiesis; B lymphopoiesis (Argiropoulos and Humphries, 2007) |
| Signalling pathwaysa | ||
| Notch | Differentiation of crystal cells (Lebestky et al., 2003) | Maintenance of HSCs; haematopoietic regeneration; regulation of differentiation (Weber and Calvi, 2010; Renstrom et al., 2010) |
| Hedgehog | Maintenance of pro-haemocytes (Mandal et al., 2007) | Lineage commitment; regulation of differentiation (Hofmann et al., 2009; Campbell et al., 2008; Gao et al., 2009) |
| Wingless (WNT) | Proliferation of PSC cells; maintenance of pro-haemocytes; differentiation of crystal cells (Sinenko et al., 2009) | Maintenance and proliferation of HSCs; regulation of B- and T-cell differentiation (Grigoryan et al., 2008) |
| JAK-STAT | Maintenance of pro-haemocytes; differentiation of lamellocytes (Krzemien et al., 2007; Harrison et al., 1995; Luo et al., 1995) | HSC renewal during regeneration; lineage commitment (Chung et al., 2006) |
| ROS/FoxO | Maintenance of pro-haemocytes (Owusu-Ansah and Banerjee, 2009) | Maintenance of HSCs; differentiation of erythroid cells (Tothova et al., 2007) |
| Pvf (PDGF/VEGF) | Differentiation of plasmatocytes (Jung et al., 2005) | Maintenance of HSCs (VEGF) (Gerber and Ferrara, 2003) |
a
Mammalian genetic or functional homologues are shown in parentheses.