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. 2011 Apr 18;4(4):484–495. doi: 10.1242/dmm.006593

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© 2011. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 2. — Acvr1^CKO lenses have increased phosphorylation of p53 at Ser15. Acvr1^WT and Acvr1^CKO lenses were stained for phosphorylated (p)-p53. (A) A representative image of an E12.5 Acvr1^WT lens with no detectable p-p53 staining. (B) p-p53-positive fiber cell nuclei were detected in Acvr1^CKO lenses at E12.5 (arrowhead). (C) The percentage of p-p53-positive fiber cells was significantly higher in Acvr1^CKO lenses than in Acvr1^WT lenses at E12.5. (D) A representative Acvr1^WT lens with no detectable p-p53-positive cells at P3. (E) An Acvr1^CKO lens with a p-p53-positive fiber cell nucleus at P3 (arrowhead). (F) At P3, significantly more p-p53-positive fiber cells were detected in Acvr1^CKO lenses than in Acvr1^WT lenses. *P<0.05. Scale bars: 20 μm (A,B), 50 μm (D,E).