Table 1.
Expected and observed survival for Drosophila wild-type and p53 mutant larvae after exposure to a combination of maytansinol and IR
| Genotype | Drug dose (μ M) | Expected survival (%) | S.d. | Observed survival (%) | S.d. |
|---|---|---|---|---|---|
| Wild type | 0.5 | 32.4 | 5.3 | 34.5 | 9.7 |
| 1 | 15.2 | 9.1 | 12.4 | 3.3 | |
| 2 | 4.0 | 1.4 | 2.3 | 1.8 | |
| p53 mutant | 0.5 | 17.9 | 8.2 | 18.1 | 8.6 |
| 1 | 3.8 | 3.0 | 4.7 | 2.8 | |
| 2 | 3.9 | 1.4 | 0.8 | 1.9 |
The values for expected and observed survival are shown for three different doses of drug. Expected numbers are computed for the scenario in which drug and radiation act in an additive manner.