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. 2011 Apr 18;4(4):548–555. doi: 10.1242/dmm.006874

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© 2011. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 2. — Formation of papilloma lesions in the UroIICre⁺Fgfr3^+/K644EK-Ras^G12D/+ model. Papilloma samples are from 12-month-old UroIICre⁺Fgfr3^+/K644EK-Ras^G12D/+ mice. H&E staining shows the formation of a papilloma (A), in which BrdU immunoreactivity demonstrated cell proliferation (B). Upregulation of pERK1/2 was observed (C), as was observed in the urothelium (Fig. 1O). However, upregulation of Sprouty2 was not present in UroIICre⁺Fgfr3^+/K644EK-Ras^G12D/+ mice (D). Neither pAKT(Ser473) (E) nor p-mTOR (F) was upregulated in papillomas formed in UroIICre⁺Fgfr3^+/K644EK-Ras^G12D/+ mice. GFP imaging indicated Cre-recombined cells in the papilloma (G). 14× magnification was used. Scale bar: 200 μm in all panels except for G.