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. 2011 Jun;178(6):2823–2831. doi: 10.1016/j.ajpath.2011.02.046

Figure 3.

Figure 3

Inflammatory infiltration of optic nerves during EAE. A–D: Representative images of optic nerve cross-sections labeled with an antibody against CD3 at EAE day 1 in WT-Prnp (A), Prnp−/− (B), WT-Tg35 (C), and Tg35 (D) mice. E: Quantification of CD3-positive cells at various stages of EAE. Compared with WT mice, significantly greater numbers of CD3-positive cells were observed in optic nerves of Tg35 mice at all stages analyzed and Prnp−/− mice at days 1 and 21 of EAE. F–I: Representative images of optic nerve cross-sections labeled with an antibody against Mac-3 at EAE day 1 in WT-Prnp (F), Prnp−/− (G), WT-Tg35 (H), and Tg35 (I) mice. J: Quantification of infiltrating Mac-3–positive cells demonstrated increased numbers of Mac-3–positive cells at all times analyzed in both Prnp−/− and Tg35 mice, as compared with their WT counterparts. Scale bars: 100 μm (A–D and F–I). *P < 0.05. **P < 0.01.