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. Author manuscript; available in PMC: 2012 Aug 1.

Published in final edited form as: Food Chem Toxicol. 2011 May 7;49(8):1863–1869. doi: 10.1016/j.fct.2011.05.004

(A) Experimental design for determining the duration of DON-induced feed refusal. Mice were given an ip. injection of DON either 0, 1, 2 or 4 hours before the dark cycle as indicated by gray inverted arrows. Food intake was measured 2 hr after the injection for a total exposure time of 2, 3, 4 and 6 h. (B) At 1 mg/kg bw DON feed refusal is attenuated within 3 h and at 5 mg/kg bw DON, feed refusal is attenuated within 6 h after exposure. Data are mean ± SEM (n = 4–5/gp). Two-Way ANOVA and Holm-Sidak post hoc tests were employed to determine the effects of dose and time on food intake. Symbols: *Food consumption for a given treatment is significantly different from treatment control at specified time (p < 0.05); ^ŧFood consumption for a given time is significantly different from 2 hr exposure time at specified dose (p < 0.05).

(A) Experimental design for determining the duration of DON-induced feed refusal. Mice were given an ip. injection of DON either 0, 1, 2 or 4 hours before the dark cycle as indicated by gray inverted arrows. Food intake was measured 2 hr after the injection for a total exposure time of 2, 3, 4 and 6 h. (B) At 1 mg/kg bw DON feed refusal is attenuated within 3 h and at 5 mg/kg bw DON, feed refusal is attenuated within 6 h after exposure. Data are mean ± SEM (n = 4–5/gp). Two-Way ANOVA and Holm-Sidak post hoc tests were employed to determine the effects of dose and time on food intake. Symbols: *Food consumption for a given treatment is significantly different from treatment control at specified time (p < 0.05); ^ŧFood consumption for a given time is significantly different from 2 hr exposure time at specified dose (p < 0.05).